Untangling the double helix : dna entanglement and the action of the dna topoisomerases / James C. Wang.

Bibliographic Details
Main Author: Wang, James C.
Language:English
Published: Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, [2009], ©2009.
Subjects:
Genre:
Physical Description:xi, 233 pages : illustrations (some color) ; 24 cm
Format: Book

MARC

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245 1 0 |a Untangling the double helix :  |b dna entanglement and the action of the dna topoisomerases /  |c James C. Wang. 
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263 |a 0904. 
300 |a xi, 233 pages :  |b illustrations (some color) ;  |c 24 cm 
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505 0 |a An insuperable problem -- Nature's solutions: the DNA topoisomerases -- Breaking a DNA strand and holding onto -- The broken ends -- A magic swivel -- Moving one DNA double helix through another -- Real-time viewing of the DNA topoisomerases in action -- Manifestations of DNA entanglement: replication and recombination -- Manifestations of DNA entanglement: transcription and gene expression -- Beyond DNA untanglement: new twists on an old -- Theme -- From nature's battlefields to the clinical wards -- Appendix 1: identification of the covalent intermediates in topoisomerase-catalyzed reactions -- Appendix 2 catalysis of dna breakage and rejoining by dna topoisomerases. 
504 |a Includes bibliographical references and index. 
650 0 |a DNA topoisomerases  |v Popular works.  |0 http://id.loc.gov/authorities/subjects/sh99000716 
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