Characterization of the development of the tonsillar microbiome in pigs / by Luis Carlos Peña Cortes.
"Pig tonsils are identified as a potential reservoir for many bacterial and viral pathogens that can survive asymptomatically in this location and may have a high potential of being zoonotic. It has been suggested that the microbiome plays a significant/ substantial role in host colonization by path...
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| Language: | English |
| Published: |
2017.
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| Dissertation Note: |
Ph. D. Michigan State University. Comparative Medicine and Integrative Biology 2017 |
| Physical Description: | 1 online resource (xii, 177 pages) : illustrations (chiefly color) |
| Format: | Thesis Electronic eBook |
MARC
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| 100 | 1 | |a Peña Cortes, Luis Carlos, |e author. | |
| 245 | 1 | 0 | |a Characterization of the development of the tonsillar microbiome in pigs / |c by Luis Carlos Peña Cortes. |
| 260 | |c 2017. | ||
| 300 | |a 1 online resource (xii, 177 pages) : |b illustrations (chiefly color) | ||
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| 502 | |b Ph. D. |c Michigan State University. Comparative Medicine and Integrative Biology |d 2017 | ||
| 504 | |a Includes bibliographical references. | ||
| 520 | 3 | |a "Pig tonsils are identified as a potential reservoir for many bacterial and viral pathogens that can survive asymptomatically in this location and may have a high potential of being zoonotic. It has been suggested that the microbiome plays a significant/ substantial role in host colonization by pathogenic microorganisms and also exerts regulatory roles in the resistance to infection. Despite the important role that the tonsillar microbiome could play in the colonization and persistence of pathogens in the host, there are no in-depth studies characterizing the development of tonsillar microbiome in pigs or how this microbiome is structured over time. Surprisingly a similar study is also absent in humans. There was a clear need to investigate the development of the tonsillar microbiome in pigs to lay the basis for future studies focused on more complex subjects such as the relationship between the normal tonsillar microbiome and pathogens in the tonsils. Understanding the development of the pig tonsillar microbiome over time and the role of the tonsillar microbiome in the acquisition and persistence of a pathogenic microorganism will lay the basis for the design of novel intervention strategies to control the presence of the pathogen and reduce the risk of transmission to other animals or humans. Moreover, these studies are expected to provide an animal model to test hypotheses generated by microbiome data that cannot be tested in humans. The goal of this study was to characterize tonsillar microbiome development in pigs, and how this microbiome is structured and how the structure changes through different times in the life of pigs. The chapters in this thesis will present pertinent data related with the composition of the pig tonsillar microbiome and how it alters through the life of pigs, possible maternal sources for some of the identified members of this microbiome, as well as the microbiome structure and progressive change through their life. Furthermore, the results will show that challenges associated with management procedures typically present in swine farms generate prominent changes in the microbiome composition and abundance of diverse bacterial families. Finally, the study will show the microscopic structure of the tonsillar epithelium and crypts and the presence of diverse bacterial communities on the surface of pig tonsils throughout different time points of their life. The final chapter will also describe the morphological changes of the tonsillar surface in pigs that are seen and are associated with changes in the microbial communities observed through different time points in their life. Taken together, the results presented here demonstrate that there is a temporal succession in the development of the pig tonsillar microbiome through the life of pigs."--Pages ii-iii. | |
| 588 | 0 | |a Online resource; title from PDF title page (viewed on May 28, 2019) | |
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| 650 | 0 | |a Tonsils |x Microbiology. |0 http://id.loc.gov/authorities/subjects/sh85136025 | |
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